Charles Crain Garr was born on October 24, 1884 to parents Charles Russell Garr and Sallie Rebecca Crain Garr. He was the first child for the couple, and would later be joined by a brother, Clyde Lewis Garr.  Charles attended local schools for his early education, before starting at Vanderbilt University when he was just 16 years old. He decided to follow in his father's footsteps and become a doctor, getting his medical degree from Hospital College of Medicine in Louisville, just as his father had. When it came time to start his career, Charles settled in Lexington, Kentucky, where he first went into medical practice.

When World War I started, Charles answered his country's call, and joined the Barrow Unit. This was a unique military unit based out of Lexington, Kentucky and made up of doctors primarily from Kentucky. After training in Oglethorpe, Georgia and doing a surgery course in New Orleans, Charles was ready to be deployed. He first went to England, where members of the Barrow Unit helped to run a hospital. Later in the war, he was sent to France, and it was from there that he returned home. Throughout his time in the war, Charles rose to the rank of Captain.

After returning from the war, Charles went back to practicing medicine in Lexington. This was most likely where he met  Elisabeth Higgins Headley , whom he married in 1921. Together the couple had two daughters, Elisabeth "Betty" Headley Garr and Charlotte Russell Garr.  Throughout his life, Charles continued to practice medicine, specializing in orthopedic surgery; he was a leader in this field in the state of Kentucky, being the third orthopedic surgeon in the state and the first in Lexington. He served as the chief surgeon for the Cheasapeake and Ohio Railroad, and was a part of the founding of the Lexington Clinic. Charles took a special interest in helping children with physical disabilities, especially from rural areas where health care was still limited in the early decades of the 20th century, such as his native Fleming County, and Eastern Kentucky. Charles often helped to get children to Lexington to  undergo surgery, and gave them a place to stay afterwards. After a long life spent in service of others, Charles passed away on July 28, 1957 at the age of 72 in Lexington. He is buried in the Lexington Cemetery.

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